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CXCR2

GENERAL INFORMATION

Gene name

 CXCR2

Gene description

 Chemokine (C-X-C motif) receptor 2

Protein class

 Cancer-related genes
CD markers
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, spleen)
GTEx:Tissue enhanced (esophagus, spleen)
FANTOM5:Tissue enhanced (lymph node, spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in a subset of leukocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA031999 , HPA032017 , CAB016268
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, spleen)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin0102030405060TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, spleen)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, spleen)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0102030405060Tags Per Million

GENE INFORMATION

Gene name

 CXCR2 (HGNC Symbol)

Synonyms

 CD182, CMKAR2, IL8RB

Description

 Chemokine (C-X-C motif) receptor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218125289 - 218137253

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180871 (version 83.38)

Entrez gene

 3579

UniProt

 P25025 (UniProt - Evidence at protein level)

neXtProt

 NX_P25025

Antibodypedia

 CXCR2 antibodies

PROTEIN BROWSER
CXCR2-001
CXCR2-002
CXCR2-003
CXCR2-004
CXCR2-005
CXCR2-006
CXCR2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCR2-001
ENSP00000319635
ENST00000318507
P25025 [Direct mapping]
C-X-C chemokine receptor type 2
Q53PC4 [Target identity:100%; Query identity:100%]
Interleukin 8 receptor, beta; Putative uncharacterized protein IL8RB; cDNA FLJ78215, highly similar to Homo sapiens interleukin 8 receptor beta (IL8RB) mRNA; cDNA, FLJ93056, Homo sapiens interleukin 8 receptor, beta (IL8RB), mRNA
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002407 [dendritic cell chemotaxis]
GO:0002438 [acute inflammatory response to antigenic stimulus]
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0004871 [signal transducer activity]
GO:0004918 [interleukin-8 receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0019959 [interleukin-8 binding]
GO:0030593 [neutrophil chemotaxis]
GO:0030901 [midbrain development]
GO:0031623 [receptor internalization]
GO:0033030 [negative regulation of neutrophil apoptotic process]
GO:0038112 [interleukin-8-mediated signaling pathway]
GO:0042119 [neutrophil activation]
GO:0042629 [mast cell granule]
GO:0043066 [negative regulation of apoptotic process]
GO:0043117 [positive regulation of vascular permeability]
GO:0045766 [positive regulation of angiogenesis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0072173 [metanephric tubule morphogenesis]
GO:0090023 [positive regulation of neutrophil chemotaxis]
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 360 aa
40.8 kDa 		No 7
CXCR2-002
ENSP00000413686
ENST00000453237
C9JW47 [Direct mapping]
C-X-C chemokine receptor type 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0019959 [interleukin-8 binding]
GO:0070098 [chemokine-mediated signaling pathway]
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 201 aa
22.7 kDa 		No 4
CXCR2-003
ENSP00000410506
ENST00000449014
Q6LCZ7 [Direct mapping]
C-X-C chemokine receptor type 2; Interleukin-8 receptor type B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 15 aa
1.9 kDa 		No 0
CXCR2-004
ENSP00000415148
ENST00000454148
C9JG19 [Direct mapping]
C-X-C chemokine receptor type 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0019959 [interleukin-8 binding]
GO:0070098 [chemokine-mediated signaling pathway]
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 136 aa
15.3 kDa 		No 3
CXCR2-005
ENSP00000392698
ENST00000428565
C9J1J7 [Direct mapping]
C-X-C chemokine receptor type 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0019959 [interleukin-8 binding]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 172 aa
19.5 kDa 		No 3
CXCR2-006
ENSP00000416815
ENST00000418878
Q6LCZ7 [Direct mapping]
C-X-C chemokine receptor type 2; Interleukin-8 receptor type B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 15 aa
1.9 kDa 		No 0
CXCR2-007
ENSP00000392348
ENST00000415392
C9J2F9 [Direct mapping]
C-X-C chemokine receptor type 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0019959 [interleukin-8 binding]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 138 aa
15.5 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.