Expression of CMTR2 in cancer - Summary - The Human Protein Atlas

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CMTR2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CMTR2
Gene description	Cap methyltransferase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA041700 , HPA048265
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041700	HPA048265

GENE INFORMATION
Gene name	CMTR2 (HGNC Symbol)
Synonyms	AFT, FLJ11171, FTSJD1, MTr2
Description	Cap methyltransferase 2 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q22.2
Chromosome location (bp)	71281389 - 71289715
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000180917 (version 83.38)
Entrez gene	55783
UniProt	Q8IYT2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IYT2
Antibodypedia	CMTR2 antibodies

PROTEIN BROWSER

CMTR2-001	CMTR2-002	CMTR2-004	CMTR2-005	CMTR2-006	CMTR2-007	CMTR2-008	CMTR2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CMTR2-001 ENSP00000337512 ENST00000338099	Q8IYT2 [Direct mapping] Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004483 [mRNA (nucleoside-2'-O-)-methyltransferase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006370 [7-methylguanosine mRNA capping] GO:0008168 [methyltransferase activity] GO:0016021 [integral component of membrane] GO:0032259 [methylation] GO:0097310 [cap2 mRNA methylation] Show all	770 aa 88.1 kDa	No	2
CMTR2-002 ENSP00000411148 ENST00000434935	Q8IYT2 [Direct mapping] Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004483 [mRNA (nucleoside-2'-O-)-methyltransferase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006370 [7-methylguanosine mRNA capping] GO:0008168 [methyltransferase activity] GO:0016021 [integral component of membrane] GO:0032259 [methylation] GO:0097310 [cap2 mRNA methylation] Show all	770 aa 88.1 kDa	No	2
CMTR2-004 ENSP00000457399 ENST00000563876	H3BTZ7 [Direct mapping] Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 18.1 kDa	No	0
CMTR2-005 ENSP00000456476 ENST00000565850	H3BS00 [Direct mapping] Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 15.1 kDa	No	0
CMTR2-006 ENSP00000457679 ENST00000568910	H3BUK2 [Direct mapping] Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.3 kDa	No	0
CMTR2-007 ENSP00000456036 ENST00000564183	H3BR19 [Direct mapping] Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 17.9 kDa	No	0
CMTR2-008 ENSP00000455080 ENST00000567610	H3BNZ8 [Direct mapping] Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 12 kDa	No	0
CMTR2-201 ENSP00000481621 ENST00000614452	A0A087WY95 [Direct mapping] Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	340 aa 38.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.