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MRPL14

GENERAL INFORMATION

Gene name

 MRPL14

Gene description

 Mitochondrial ribosomal protein L14

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA038769
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), thyroid cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Thyroid cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038769

GENE INFORMATION

Gene name

 MRPL14 (HGNC Symbol)

Synonyms

 MRP-L32, RPML32

Description

 Mitochondrial ribosomal protein L14 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found at 17p13.3. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 44113454 - 44127457

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000180992 (version 83.38)

Entrez gene

 64928

UniProt

 Q6P1L8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P1L8

Antibodypedia

 MRPL14 antibodies

PROTEIN BROWSER
MRPL14-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL14-001
ENSP00000361084
ENST00000372014
Q6P1L8 [Direct mapping]
39S ribosomal protein L14, mitochondrial
A0A024RD78 [Target identity:100%; Query identity:100%]
Mitochondrial ribosomal protein L14, isoform CRA_b
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Ribosomal proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 145 aa
15.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.