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AEN

GENERAL INFORMATION

Gene name

 AEN

Gene description

 Apoptosis enhancing nuclease

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 AEN (HGNC Symbol)

Synonyms

 FLJ12484, FLJ12562, ISG20L1

Description

 Apoptosis enhancing nuclease (HGNC Symbol)

Entrez gene summary

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 88621296 - 88632282

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181026 (version 83.38)

Entrez gene

 64782

UniProt

 Q8WTP8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WTP8

Antibodypedia

 AEN antibodies

PROTEIN BROWSER
AEN-001
AEN-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AEN-001
ENSP00000331944
ENST00000332810
Q8WTP8 [Direct mapping]
Apoptosis-enhancing nuclease
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0010212 [response to ionizing radiation]
GO:0031965 [nuclear membrane]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 325 aa
36.4 kDa 		No 0
AEN-004
ENSP00000453631
ENST00000559528
H0YMJ6 [Direct mapping]
Apoptosis-enhancing nuclease
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0031965 [nuclear membrane]
Show all
 179 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.