Expression of CHRM2 in cancer - Summary - The Human Protein Atlas

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CHRM2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHRM2
Gene description	Cholinergic receptor, muscarinic 2
Protein class	Disease related genes FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (stomach cancer)
HPA (cell line):	Group enriched (BJ, BJ hTERT+, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (gallbladder, heart muscle, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression in all tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA029795 , CAB022338
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029795	CAB022338

GENE INFORMATION
Gene name	CHRM2
Synonyms
Description	Cholinergic receptor, muscarinic 2 (HGNC Symbol)
Entrez gene summary	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q33
Chromosome location (bp)	136868669 - 137020255
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181072 (version 83.38)
Entrez gene	1129
UniProt	P08172 (UniProt - Evidence at protein level)
neXtProt	NX_P08172
Antibodypedia	CHRM2 antibodies

PROTEIN BROWSER

CHRM2-001	CHRM2-003	CHRM2-004	CHRM2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHRM2-001 ENSP00000399745 ENST00000445907	P08172 [Direct mapping] Muscarinic acetylcholine receptor M2 A4D1Q0 [Target identity:100%; Query identity:100%] Muscarinic acetylcholine receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006940 [regulation of smooth muscle contraction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007606 [sensory perception of chemical stimulus] GO:0008016 [regulation of heart contraction] GO:0008144 [drug binding] GO:0009615 [response to virus] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016907 [G-protein coupled acetylcholine receptor activity] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0032279 [asymmetric synapse] GO:0032280 [symmetric synapse] GO:0043025 [neuronal cell body] GO:0043679 [axon terminus] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] Show all	466 aa 51.7 kDa	No	7
CHRM2-003 ENSP00000384401 ENST00000401861	P08172 [Direct mapping] Muscarinic acetylcholine receptor M2 A4D1Q0 [Target identity:100%; Query identity:100%] Muscarinic acetylcholine receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006940 [regulation of smooth muscle contraction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007606 [sensory perception of chemical stimulus] GO:0008016 [regulation of heart contraction] GO:0009615 [response to virus] GO:0016021 [integral component of membrane] GO:0016907 [G-protein coupled acetylcholine receptor activity] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] Show all	466 aa 51.7 kDa	No	7
CHRM2-004 ENSP00000415386 ENST00000453373	P08172 [Direct mapping] Muscarinic acetylcholine receptor M2 A4D1Q0 [Target identity:100%; Query identity:100%] Muscarinic acetylcholine receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006940 [regulation of smooth muscle contraction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007606 [sensory perception of chemical stimulus] GO:0008016 [regulation of heart contraction] GO:0009615 [response to virus] GO:0016021 [integral component of membrane] GO:0016907 [G-protein coupled acetylcholine receptor activity] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] Show all	466 aa 51.7 kDa	No	7
CHRM2-007 ENSP00000319984 ENST00000320658	P08172 [Direct mapping] Muscarinic acetylcholine receptor M2 A4D1Q0 [Target identity:100%; Query identity:100%] Muscarinic acetylcholine receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006940 [regulation of smooth muscle contraction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007399 [nervous system development] GO:0007606 [sensory perception of chemical stimulus] GO:0008016 [regulation of heart contraction] GO:0009615 [response to virus] GO:0016021 [integral component of membrane] GO:0016907 [G-protein coupled acetylcholine receptor activity] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] Show all	466 aa 51.7 kDa	No	7

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