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Cytoplasmic and plasma positivity in several tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.
Several skin cancers along with a few cases of endometrial, cervical, renal and liver cancers cancer displayed moderate to strong cytoplasmic staining. Remaining cancer cells were negative.
GENE INFORMATION
Gene name
ADIPOQ (HGNC Symbol)
Synonyms
ACDC, ACRP30, adiponectin, AdipoQ, apM1, GBP28
Description
Adiponectin, C1Q and collagen domain containing (HGNC Symbol)
Entrez gene summary
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]