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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADIPOQ
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADIPOQ

Gene description

Adiponectin, C1Q and collagen domain containing

Protein class

Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (breast cancer, pancreatic cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and plasma positivity in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.

Reliability score

Uncertain based on 2 antibodies.
HPA051767 , CAB046467
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (breast cancer, pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA051767
CAB046467

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several hepatocellular carcinomas and skin cancers exhibited weak to moderate cytoplasmic immunoreactivity. Remaining cancers were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several skin cancers along with a few cases of endometrial, cervical, renal and liver cancers cancer displayed moderate to strong cytoplasmic staining. Remaining cancer cells were negative.

GENE INFORMATION

Gene name

ADIPOQ (HGNC Symbol)

Synonyms

ACDC, ACRP30, adiponectin, AdipoQ, apM1, GBP28

Description

Adiponectin, C1Q and collagen domain containing (HGNC Symbol)

Entrez gene summary

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Chromosome

3

Cytoband

q27.3

Chromosome location (bp)

186842690 - 186858463

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181092 (version 83.38)

Entrez gene

9370

UniProt

Q15848 (UniProt - Evidence at protein level)

neXtProt

NX_Q15848

Antibodypedia

ADIPOQ antibodies

PROTEIN BROWSER

ADIPOQ-001
ADIPOQ-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADIPOQ-001
ENSP00000389814
ENST00000444204
Q15848 [Direct mapping]
Adiponectin
A8K660 [Target identity:100%; Query identity:100%]
Adiponectin; Adiponectin, C1Q and collagen domain containing; cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006635 [fatty acid beta-oxidation]
GO:0007584 [response to nutrient]
GO:0007623 [circadian rhythm]
GO:0009744 [response to sucrose]
GO:0009749 [response to glucose]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010906 [regulation of glucose metabolic process]
GO:0014823 [response to activity]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0019395 [fatty acid oxidation]
GO:0030336 [negative regulation of cell migration]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031667 [response to nutrient levels]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0033034 [positive regulation of myeloid cell apoptotic process]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0033691 [sialic acid binding]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034612 [response to tumor necrosis factor]
GO:0035690 [cellular response to drug]
GO:0042493 [response to drug]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045471 [response to ethanol]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0046888 [negative regulation of hormone secretion]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050765 [negative regulation of phagocytosis]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050873 [brown fat cell differentiation]
GO:0051260 [protein homooligomerization]
GO:0051384 [response to glucocorticoid]
GO:0051899 [membrane depolarization]
GO:0060081 [membrane hyperpolarization]
GO:0070062 [extracellular exosome]
GO:0070208 [protein heterotrimerization]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070543 [response to linoleic acid]
GO:0070994 [detection of oxidative stress]
GO:0071320 [cellular response to cAMP]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0072659 [protein localization to plasma membrane]
GO:0090317 [negative regulation of intracellular protein transport]
GO:1900121 [negative regulation of receptor binding]
GO:2000279 [negative regulation of DNA biosynthetic process]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
GO:2000478 [positive regulation of metanephric glomerular visceral epithelial cell development]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
GO:2000534 [positive regulation of renal albumin absorption]
GO:2000584 [negative regulation of platelet-derived growth factor receptor-alpha signaling pathway]
GO:2000590 [negative regulation of metanephric mesenchymal cell migration]
Show all
244 aa
26.4 kDa
Yes 0
ADIPOQ-002
ENSP00000320709
ENST00000320741
Q15848 [Direct mapping]
Adiponectin
A8K660 [Target identity:100%; Query identity:100%]
Adiponectin; Adiponectin, C1Q and collagen domain containing; cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005102 [receptor binding]
GO:0005125 [cytokine activity]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005783 [endoplasmic reticulum]
GO:0006006 [glucose metabolic process]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006635 [fatty acid beta-oxidation]
GO:0009749 [response to glucose]
GO:0009967 [positive regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010739 [positive regulation of protein kinase A signaling]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010906 [regulation of glucose metabolic process]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0019395 [fatty acid oxidation]
GO:0030336 [negative regulation of cell migration]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0033034 [positive regulation of myeloid cell apoptotic process]
GO:0033691 [sialic acid binding]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034383 [low-density lipoprotein particle clearance]
GO:0034612 [response to tumor necrosis factor]
GO:0035690 [cellular response to drug]
GO:0042593 [glucose homeostasis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045650 [negative regulation of macrophage differentiation]
GO:0045715 [negative regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045776 [negative regulation of blood pressure]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045923 [positive regulation of fatty acid metabolic process]
GO:0046326 [positive regulation of glucose import]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050765 [negative regulation of phagocytosis]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050873 [brown fat cell differentiation]
GO:0051260 [protein homooligomerization]
GO:0070062 [extracellular exosome]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070994 [detection of oxidative stress]
GO:0071639 [positive regulation of monocyte chemotactic protein-1 production]
GO:0072659 [protein localization to plasma membrane]
GO:0090317 [negative regulation of intracellular protein transport]
GO:1900121 [negative regulation of receptor binding]
GO:2000279 [negative regulation of DNA biosynthetic process]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]
GO:2000478 [positive regulation of metanephric glomerular visceral epithelial cell development]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
GO:2000534 [positive regulation of renal albumin absorption]
GO:2000584 [negative regulation of platelet-derived growth factor receptor-alpha signaling pathway]
GO:2000590 [negative regulation of metanephric mesenchymal cell migration]
Show all
244 aa
26.4 kDa
Yes 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.