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NPM1

GENERAL INFORMATION

Gene name

 NPM1

Gene description

 Nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA011384 , CAB012983
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NPM1 (HGNC Symbol)

Synonyms

 B23, NPM

Description

 Nucleophosmin (nucleolar phosphoprotein B23, numatrin) (HGNC Symbol)

Entrez gene summary

 This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

Chromosome

 5

Cytoband

 q35.1

Chromosome location (bp)

 171387116 - 171411137

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181163 (version 83.38)

Entrez gene

 4869

UniProt

 P06748 (UniProt - Evidence at protein level)

neXtProt

 NX_P06748

Antibodypedia

 NPM1 antibodies

PROTEIN BROWSER
NPM1-001
NPM1-002
NPM1-003
NPM1-004
NPM1-005
NPM1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPM1-001
ENSP00000296930
ENST00000296930
P06748 [Direct mapping]
Nucleophosmin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006334 [nucleosome assembly]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006950 [response to stress]
GO:0007098 [centrosome cycle]
GO:0007165 [signal transduction]
GO:0007569 [cell aging]
GO:0008104 [protein localization]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010826 [negative regulation of centrosome duplication]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030529 [ribonucleoprotein complex]
GO:0030957 [Tat protein binding]
GO:0031616 [spindle pole centrosome]
GO:0032071 [regulation of endodeoxyribonuclease activity]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042255 [ribosome assembly]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0043023 [ribosomal large subunit binding]
GO:0043024 [ribosomal small subunit binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046599 [regulation of centriole replication]
GO:0046982 [protein heterodimerization activity]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0060699 [regulation of endoribonuclease activity]
GO:0060735 [regulation of eIF2 alpha phosphorylation by dsRNA]
GO:1902751 [positive regulation of cell cycle G2/M phase transition]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 294 aa
32.6 kDa 		No 0
NPM1-002
ENSP00000341168
ENST00000351986
P06748 [Direct mapping]
Nucleophosmin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006334 [nucleosome assembly]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006950 [response to stress]
GO:0007098 [centrosome cycle]
GO:0007165 [signal transduction]
GO:0007569 [cell aging]
GO:0008104 [protein localization]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010826 [negative regulation of centrosome duplication]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030529 [ribonucleoprotein complex]
GO:0030957 [Tat protein binding]
GO:0031616 [spindle pole centrosome]
GO:0032071 [regulation of endodeoxyribonuclease activity]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042255 [ribosome assembly]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0043023 [ribosomal large subunit binding]
GO:0043024 [ribosomal small subunit binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046599 [regulation of centriole replication]
GO:0046982 [protein heterodimerization activity]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0060699 [regulation of endoribonuclease activity]
GO:0060735 [regulation of eIF2 alpha phosphorylation by dsRNA]
GO:1902751 [positive regulation of cell cycle G2/M phase transition]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 265 aa
29.5 kDa 		No 0
NPM1-003
ENSP00000377408
ENST00000393820
P06748 [Direct mapping]
Nucleophosmin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006334 [nucleosome assembly]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006950 [response to stress]
GO:0007098 [centrosome cycle]
GO:0007165 [signal transduction]
GO:0007569 [cell aging]
GO:0008104 [protein localization]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010826 [negative regulation of centrosome duplication]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030529 [ribonucleoprotein complex]
GO:0030957 [Tat protein binding]
GO:0031616 [spindle pole centrosome]
GO:0032071 [regulation of endodeoxyribonuclease activity]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042255 [ribosome assembly]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0043023 [ribosomal large subunit binding]
GO:0043024 [ribosomal small subunit binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046599 [regulation of centriole replication]
GO:0046982 [protein heterodimerization activity]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0060699 [regulation of endoribonuclease activity]
GO:0060735 [regulation of eIF2 alpha phosphorylation by dsRNA]
GO:1902751 [positive regulation of cell cycle G2/M phase transition]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 259 aa
28.4 kDa 		No 0
NPM1-004
ENSP00000428755
ENST00000517671
P06748 [Direct mapping]
Nucleophosmin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0003723 [RNA binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006281 [DNA repair]
GO:0006334 [nucleosome assembly]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006950 [response to stress]
GO:0007098 [centrosome cycle]
GO:0007165 [signal transduction]
GO:0007569 [cell aging]
GO:0008104 [protein localization]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010826 [negative regulation of centrosome duplication]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0030529 [ribonucleoprotein complex]
GO:0030957 [Tat protein binding]
GO:0031616 [spindle pole centrosome]
GO:0032071 [regulation of endodeoxyribonuclease activity]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0042255 [ribosome assembly]
GO:0042393 [histone binding]
GO:0042803 [protein homodimerization activity]
GO:0043023 [ribosomal large subunit binding]
GO:0043024 [ribosomal small subunit binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044387 [negative regulation of protein kinase activity by regulation of protein phosphorylation]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046599 [regulation of centriole replication]
GO:0046982 [protein heterodimerization activity]
GO:0051059 [NF-kappaB binding]
GO:0051082 [unfolded protein binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0060699 [regulation of endoribonuclease activity]
GO:0060735 [regulation of eIF2 alpha phosphorylation by dsRNA]
GO:1902751 [positive regulation of cell cycle G2/M phase transition]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 294 aa
32.6 kDa 		No 0
NPM1-005
ENSP00000429485
ENST00000521672
E5RI98 [Direct mapping]
Nucleophosmin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
Show all
 111 aa
11.9 kDa 		No 0
NPM1-007
ENSP00000428647
ENST00000523622
E5RGW4 [Direct mapping]
Nucleophosmin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
Show all
 59 aa
6.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.