Expression of HIST3H2A in cancer - Summary - The Human Protein Atlas

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HIST3H2A

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HIST3H2A
Gene description	Histone cluster 3, H2a
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).
Reliability score	Supported based on 1 antibody. HPA041189
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041189

GENE INFORMATION
Gene name	HIST3H2A (HGNC Symbol)
Synonyms	MGC3165
Description	Histone cluster 3, H2a (HGNC Symbol)
Entrez gene summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Chromosome	1
Cytoband	q42.13
Chromosome location (bp)	228456979 - 228457873
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181218 (version 83.38)
Entrez gene	92815
UniProt	Q7L7L0 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L7L0
Antibodypedia	HIST3H2A antibodies

PROTEIN BROWSER

HIST3H2A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HIST3H2A-001 ENSP00000355656 ENST00000366695	Q7L7L0 [Direct mapping] Histone H2A type 3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0000786 [nucleosome] GO:0000788 [nuclear nucleosome] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006342 [chromatin silencing] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] GO:0070914 [UV-damage excision repair] Show all	130 aa 14.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.