Expression of FRAT2 in cancer - Summary - The Human Protein Atlas

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FRAT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FRAT2
Gene description	Frequently rearranged in advanced T-cell lymphomas 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA049763
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049763

GENE INFORMATION
Gene name	FRAT2
Synonyms
Description	Frequently rearranged in advanced T-cell lymphomas 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	97332497 - 97334709
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000181274 (version 83.38)
Entrez gene	23401
UniProt	O75474 (UniProt - Evidence at transcript level)
neXtProt	NX_O75474
Antibodypedia	FRAT2 antibodies

PROTEIN BROWSER

FRAT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FRAT2-001 ENSP00000360058 ENST00000371019	O75474 [Direct mapping] GSK-3-binding protein FRAT2 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0007275 [multicellular organismal development] GO:0008283 [cell proliferation] GO:0016055 [Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	233 aa 24.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.