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CCL13

GENERAL INFORMATION

Gene name

 CCL13

Gene description

 Chemokine (C-C motif) ligand 13

Protein class

 Cancer-related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BJ hTERT+, BJ hTERT+ SV40 Large T+ RasG12V, HMC-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CCL13 (HGNC Symbol)

Synonyms

 CKb10, MCP-4, MGC17134, NCC-1, SCYA13, SCYL1

Description

 Chemokine (C-C motif) ligand 13 (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 34356452 - 34358610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181374 (version 83.38)

Entrez gene

 6357

UniProt

 Q99616 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99616

Antibodypedia

 CCL13 antibodies

PROTEIN BROWSER
CCL13-001
CCL13-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL13-001
ENSP00000225844
ENST00000225844
Q99616 [Direct mapping]
C-C motif chemokine 13 C-C motif chemokine 13, long chain C-C motif chemokine 13, medium chain C-C motif chemokine 13, short chain
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
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GO:0002548 [monocyte chemotaxis]
GO:0005102 [receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008360 [regulation of cell shape]
GO:0030593 [neutrophil chemotaxis]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
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 98 aa
11 kDa 		Yes 0
CCL13-002
ENSP00000463667
ENST00000577681
J3QLQ9 [Direct mapping]
C-C motif chemokine 13
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Predicted intracellular proteins
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GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0060326 [cell chemotaxis]
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 63 aa
7.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.