Expression of SAGE1 in cancer - Summary - The Human Protein Atlas

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SAGE1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SAGE1
Gene description	Sarcoma antigen 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (AN3-CA, K-562, Karpas-707, U-2 OS, U-266/70, U-266/84)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective nuclear expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA003033 , HPA003208
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003033	HPA003208

GENE INFORMATION
Gene name	SAGE1 (HGNC Symbol)
Synonyms	CT14, SAGE
Description	Sarcoma antigen 1 (HGNC Symbol)
Entrez gene summary	This gene belongs to a class of genes that are activated in tumors. These genes are expressed in tumors of different histologic types but not in normal tissues, except for spermatogenic cells and, for some, placenta. The proteins encoded by these genes appear to be strictly tumor specific, and hence may be excellent sources of antigens for cancer immunotherapy. This gene is expressed in sarcomas. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q26.3
Chromosome location (bp)	135889205 - 135913061
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181433 (version 83.38)
Entrez gene	55511
UniProt	Q9NXZ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NXZ1
Antibodypedia	SAGE1 antibodies

PROTEIN BROWSER

SAGE1-001	SAGE1-201	SAGE1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SAGE1-001 ENSP00000359743 ENST00000370709	Q9NXZ1 [Direct mapping] Sarcoma antigen 1 Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] Show all	904 aa 99.2 kDa	No	0
SAGE1-201 ENSP00000323191 ENST00000324447	Q9NXZ1 [Direct mapping] Sarcoma antigen 1 Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] Show all	904 aa 99.2 kDa	No	0
SAGE1-202 ENSP00000438276 ENST00000537770	F5H2Z8 [Direct mapping] Sarcoma antigen 1 Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] Show all	528 aa 58.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.