Expression of TMEM45A in cancer - Summary - The Human Protein Atlas

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TMEM45A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM45A
Gene description	Transmembrane protein 45A
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in basal cells in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA062101
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA062101

GENE INFORMATION
Gene name	TMEM45A (HGNC Symbol)
Synonyms	DERP7, FLJ10134
Description	Transmembrane protein 45A (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q12.2
Chromosome location (bp)	100492619 - 100577444
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181458 (version 83.38)
Entrez gene	55076
UniProt	Q9NWC5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NWC5
Antibodypedia	TMEM45A antibodies

PROTEIN BROWSER

TMEM45A-001	TMEM45A-002	TMEM45A-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM45A-001 ENSP00000319009 ENST00000323523	Q9NWC5 [Direct mapping] Transmembrane protein 45A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	275 aa 31.7 kDa	No	7
TMEM45A-002 ENSP00000385089 ENST00000403410	J3KQ06 [Direct mapping] Transmembrane protein 45A; Transmembrane protein 45A, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	291 aa 33.5 kDa	No	7
TMEM45A-004 ENSP00000405597 ENST00000449609	C9J9Z5 [Direct mapping] Transmembrane protein 45A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	191 aa 21.9 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.