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FANCB

GENERAL INFORMATION

Gene name

 FANCB

Gene description

 Fanconi anemia, complementation group B

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA003124
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003124

GENE INFORMATION

Gene name

 FANCB (HGNC Symbol)

Synonyms

 FAAP95, FAB, FLJ34064

Description

 Fanconi anemia, complementation group B (HGNC Symbol)

Entrez gene summary

 The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group B. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 14843407 - 14873069

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181544 (version 83.38)

Entrez gene

 2187

UniProt

 Q8NB91 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NB91

Antibodypedia

 FANCB antibodies

PROTEIN BROWSER
FANCB-001
FANCB-002
FANCB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FANCB-001
ENSP00000326819
ENST00000324138
Q8NB91 [Direct mapping]
Fanconi anemia group B protein
A0A024RBW1 [Target identity:100%; Query identity:100%]
Fanconi anemia, complementation group B, isoform CRA_a
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0036297 [interstrand cross-link repair]
GO:0043240 [Fanconi anaemia nuclear complex]
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 859 aa
97.7 kDa 		No 0
FANCB-002
ENSP00000397849
ENST00000452869
C9J5X9 [Direct mapping]
Fanconi anemia group B protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 818 aa
93.1 kDa 		No 0
FANCB-201
ENSP00000381378
ENST00000398334
Q8NB91 [Direct mapping]
Fanconi anemia group B protein
A0A024RBW1 [Target identity:100%; Query identity:100%]
Fanconi anemia, complementation group B, isoform CRA_a
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0036297 [interstrand cross-link repair]
GO:0043240 [Fanconi anaemia nuclear complex]
Show all
 859 aa
97.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.