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MRPS23

GENERAL INFORMATION

Gene name

 MRPS23

Gene description

 Mitochondrial ribosomal protein S23

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular, mitochondrial pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA023453
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023453

GENE INFORMATION

Gene name

 MRPS23 (HGNC Symbol)

Synonyms

 CGI-138, HSPC329, MRP-S23

Description

 Mitochondrial ribosomal protein S23 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q22

Chromosome location (bp)

 57834781 - 57850056

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181610 (version 83.38)

Entrez gene

 51649

UniProt

 Q9Y3D9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3D9

Antibodypedia

 MRPS23 antibodies

PROTEIN BROWSER
MRPS23-001
MRPS23-003
MRPS23-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPS23-001
ENSP00000320184
ENST00000313608
Q9Y3D9 [Direct mapping]
28S ribosomal protein S23, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0031965 [nuclear membrane]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 190 aa
21.8 kDa 		No 0
MRPS23-003
ENSP00000463481
ENST00000579380
J3QLC1 [Direct mapping]
28S ribosomal protein S23, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 61 aa
6.9 kDa 		No 0
MRPS23-004
ENSP00000463677
ENST00000578444
J3QLR8 [Direct mapping]
28S ribosomal protein S23, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 152 aa
17.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.