Cell atlas - PHLDA2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PHLDA2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PHLDA2
Gene description	Pleckstrin homology-like domain, family A, member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Cell line enhanced (HDLM-2, WM-115, PC-3, SK-MEL-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA003994
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, WM-115, PC-3, SK-MEL-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003994	MCF7	Nucleoli
	HPA003994	U-2 OS	No staining

GENE INFORMATION
Gene name	PHLDA2 (HGNC Symbol)
Synonyms	BWR1C, HLDA2, IPL, TSSC3
Description	Pleckstrin homology-like domain, family A, member 2 (HGNC Symbol)
Entrez gene summary	This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	2928273 - 2929455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181649 (version 83.38)
Entrez gene	7262
UniProt	Q53GA4 (UniProt - Evidence at protein level)
neXtProt	NX_Q53GA4
Antibodypedia	PHLDA2 antibodies

PROTEIN BROWSER

PHLDA2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHLDA2-001 ENSP00000319231 ENST00000314222	Q53GA4 [Direct mapping] Pleckstrin homology-like domain family A member 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001890 [placenta development] GO:0005737 [cytoplasm] GO:0006915 [apoptotic process] GO:0009887 [organ morphogenesis] GO:0010468 [regulation of gene expression] GO:0016020 [membrane] GO:0030334 [regulation of cell migration] GO:0045995 [regulation of embryonic development] GO:0070873 [regulation of glycogen metabolic process] Show all	152 aa 17.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.