Expression of GPR88 in cancer - Summary - The Human Protein Atlas

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GPR88

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPR88
Gene description	G protein-coupled receptor 88
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (SCLC-21H)
HPA (normal tissue):	Group enriched (breast, cerebral cortex, liver, ovary, parathyroid gland, spleen)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA007488
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007488

GENE INFORMATION
Gene name	GPR88
Synonyms
Description	G protein-coupled receptor 88 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p21.2
Chromosome location (bp)	100538137 - 100542018
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000181656 (version 83.38)
Entrez gene	54112
UniProt	Q9GZN0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9GZN0
Antibodypedia	GPR88 antibodies

PROTEIN BROWSER

GPR88-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR88-001 ENSP00000314223 ENST00000315033	Q9GZN0 [Direct mapping] Probable G-protein coupled receptor 88 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005575 [cellular_component] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007626 [locomotory behavior] GO:0016021 [integral component of membrane] GO:0019228 [neuronal action potential] GO:0050885 [neuromuscular process controlling balance] Show all	384 aa 40.2 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.