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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HKR1
  • TISSUE

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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HKR1

Gene description

HKR1, GLI-Kruppel zinc finger family member

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

18
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA036126
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in prostate cancer (unfavourable) and pancreatic cancer (favourable).
Prostate cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA036126

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant gliomas and several cases of malignant carcinoids and hepatocellular carcinomas as well as a few cases of basal cell carcinomas, prostate and endometrial cancers displayed moderate to strong nuclear/nuclear membranous staining. Additional cytoplasmic positivity was observed in a few cases. Remaining malignant cells were weakly stained or negative.

GENE INFORMATION

Gene name

HKR1 (HGNC Symbol)

Synonyms

ZNF875

Description

HKR1, GLI-Kruppel zinc finger family member (HGNC Symbol)

Entrez gene summary

Chromosome

19

Cytoband

q13.12

Chromosome location (bp)

37312837 - 37369365

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181666 (version 83.38)

Entrez gene

284459

UniProt

P10072 (UniProt - Evidence at transcript level)

neXtProt

NX_P10072

Antibodypedia

HKR1 antibodies

PROTEIN BROWSER

«
HKR1-001
HKR1-002
HKR1-003
HKR1-004
HKR1-006
HKR1-007
HKR1-010
HKR1-012
HKR1-013
HKR1-014
HKR1-015
HKR1-016
HKR1-017
HKR1-020
HKR1-021
HKR1-024
HKR1-026
HKR1-027
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HKR1-001
ENSP00000315505
ENST00000324411
P10072 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0046872 [metal ion binding]
Show all
659 aa
75.1 kDa
No 0
HKR1-002
ENSP00000466472
ENST00000591259
K7EME6 [Direct mapping]
GLI-Kruppel family member HKR1, isoform CRA_d; Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
171 aa
19.4 kDa
No 0
HKR1-003
ENSP00000467562
ENST00000589392
K7EPW3 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
641 aa
73.2 kDa
No 0
HKR1-004
ENSP00000375994
ENST00000392153
P10072 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0046872 [metal ion binding]
Show all
640 aa
73.1 kDa
No 0
HKR1-006
ENSP00000437774
ENST00000544914
F5H6A5 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
386 aa
44.4 kDa
No 0
HKR1-007
ENSP00000466467
ENST00000591471
F5H6A5 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
386 aa
44.4 kDa
No 0
HKR1-010
ENSP00000468528
ENST00000589801
K7ES32 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
37 aa
4 kDa
No 0
HKR1-012
ENSP00000465297
ENST00000589188
K7EJS1 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
22 aa
2.5 kDa
No 0
HKR1-013
ENSP00000466498
ENST00000590582
K7EMG8 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
132 aa
15 kDa
No 0
HKR1-014
ENSP00000465884
ENST00000592768
K7EL22 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
107 aa
12.3 kDa
No 0
HKR1-015
ENSP00000465899
ENST00000591417
K7EL36 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
91 aa
10.3 kDa
No 0
HKR1-016
ENSP00000466360
ENST00000585623
K7EM51 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
77 aa
8.8 kDa
No 0
HKR1-017
ENSP00000467822
ENST00000592168
K7EQG8 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
54 aa
6 kDa
No 0
HKR1-020
ENSP00000438261
ENST00000541583
Q7Z6E1 [Direct mapping]
HKR1 protein; Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
598 aa
68.2 kDa
No 0
HKR1-021
ENSP00000468572
ENST00000590166
K7EJS1 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
22 aa
2.5 kDa
No 0
HKR1-024
ENSP00000468176
ENST00000591391
K7ERA5 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
127 aa
14.6 kDa
No 0
HKR1-026
ENSP00000466856
ENST00000591134
K7ENA5 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
46 aa
5.3 kDa
No 0
HKR1-027
ENSP00000465862
ENST00000586897
K7EL05 [Direct mapping]
Krueppel-related zinc finger protein 1
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
91 aa
10.3 kDa
No 0

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The Human Protein Atlas project is funded
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