Expression of HKR1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HKR1
Gene description	HKR1, GLI-Kruppel zinc finger family member
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036126
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable) and pancreatic cancer (favourable).
Prostate cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA036126

GENE INFORMATION
Gene name	HKR1 (HGNC Symbol)
Synonyms	ZNF875
Description	HKR1, GLI-Kruppel zinc finger family member (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	37312837 - 37369365
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181666 (version 83.38)
Entrez gene	284459
UniProt	P10072 (UniProt - Evidence at transcript level)
neXtProt	NX_P10072
Antibodypedia	HKR1 antibodies

PROTEIN BROWSER

HKR1-001	HKR1-002	HKR1-003	HKR1-004	HKR1-006	HKR1-007	HKR1-010	HKR1-012	HKR1-013	HKR1-014	HKR1-015	HKR1-016	HKR1-017	HKR1-020	HKR1-021	HKR1-024	HKR1-026	HKR1-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HKR1-001 ENSP00000315505 ENST00000324411	P10072 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0046872 [metal ion binding] Show all	659 aa 75.1 kDa	No	0
HKR1-002 ENSP00000466472 ENST00000591259	K7EME6 [Direct mapping] GLI-Kruppel family member HKR1, isoform CRA_d; Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	171 aa 19.4 kDa	No	0
HKR1-003 ENSP00000467562 ENST00000589392	K7EPW3 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	641 aa 73.2 kDa	No	0
HKR1-004 ENSP00000375994 ENST00000392153	P10072 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0046872 [metal ion binding] Show all	640 aa 73.1 kDa	No	0
HKR1-006 ENSP00000437774 ENST00000544914	F5H6A5 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	386 aa 44.4 kDa	No	0
HKR1-007 ENSP00000466467 ENST00000591471	F5H6A5 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	386 aa 44.4 kDa	No	0
HKR1-010 ENSP00000468528 ENST00000589801	K7ES32 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		37 aa 4 kDa	No	0
HKR1-012 ENSP00000465297 ENST00000589188	K7EJS1 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all		22 aa 2.5 kDa	No	0
HKR1-013 ENSP00000466498 ENST00000590582	K7EMG8 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		132 aa 15 kDa	No	0
HKR1-014 ENSP00000465884 ENST00000592768	K7EL22 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	107 aa 12.3 kDa	No	0
HKR1-015 ENSP00000465899 ENST00000591417	K7EL36 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	91 aa 10.3 kDa	No	0
HKR1-016 ENSP00000466360 ENST00000585623	K7EM51 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	77 aa 8.8 kDa	No	0
HKR1-017 ENSP00000467822 ENST00000592168	K7EQG8 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	54 aa 6 kDa	No	0
HKR1-020 ENSP00000438261 ENST00000541583	Q7Z6E1 [Direct mapping] HKR1 protein; Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	598 aa 68.2 kDa	No	0
HKR1-021 ENSP00000468572 ENST00000590166	K7EJS1 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all		22 aa 2.5 kDa	No	0
HKR1-024 ENSP00000468176 ENST00000591391	K7ERA5 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	127 aa 14.6 kDa	No	0
HKR1-026 ENSP00000466856 ENST00000591134	K7ENA5 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	46 aa 5.3 kDa	No	0
HKR1-027 ENSP00000465862 ENST00000586897	K7EL05 [Direct mapping] Krueppel-related zinc finger protein 1 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] Show all	91 aa 10.3 kDa	No	0