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Most cancers displayed moderate nuclear positivity. Few cases lymphoma and skin cancers along with rare liver, urothelial and cervical cancers showed strong positivity. The majority of prostate, renal and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
SIAH2
Synonyms
Description
Siah E3 ubiquitin protein ligase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]