Expression of SLC9A9 in cancer - Summary - The Human Protein Atlas

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SLC9A9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC9A9
Gene description	Solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, Karpas-707, RPMI-8226, U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic and membrane expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA058234
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058234

GENE INFORMATION
Gene name	SLC9A9 (HGNC Symbol)
Synonyms	FLJ35613, NHE9
Description	Solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a sodium/proton exchanger that is a member of the solute carrier 9 protein family. The encoded protein localizes the to the late recycling endosomes and may play an important role in maintaining cation homeostasis. Mutations in this gene are associated with autism susceptibility 16 and attention-deficit/hyperactivity disorder. [provided by RefSeq, Mar 2012]
Chromosome	3
Cytoband	q24
Chromosome location (bp)	143265222 - 143848531
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181804 (version 83.38)
Entrez gene	285195
UniProt	Q8IVB4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVB4
Antibodypedia	SLC9A9 antibodies

PROTEIN BROWSER

SLC9A9-001	SLC9A9-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A9-001 ENSP00000320246 ENST00000316549	Q8IVB4 [Direct mapping] Sodium/hydrogen exchanger 9 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0031902 [late endosome membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055037 [recycling endosome] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	645 aa 72.6 kDa	No	>9
SLC9A9-004 ENSP00000418627 ENST00000474151	C9IZP1 [Direct mapping] Sodium/hydrogen exchanger 9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006885 [regulation of pH] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	147 aa 17 kDa	No	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.