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SLC2A4

GENERAL INFORMATION

Gene name

 SLC2A4

Gene description

 Solute carrier family 2 (facilitated glucose transporter), member 4

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle, skeletal muscle)
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in myocytes and adipocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB016544
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION

Gene name

 SLC2A4 (HGNC Symbol)

Synonyms

 GLUT4

Description

 Solute carrier family 2 (facilitated glucose transporter), member 4 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7281667 - 7288257

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181856 (version 83.38)

Entrez gene

 6517

UniProt

 P14672 (UniProt - Evidence at protein level)

neXtProt

 NX_P14672

Antibodypedia

 SLC2A4 antibodies

PROTEIN BROWSER
SLC2A4-001
SLC2A4-003
SLC2A4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC2A4-001
ENSP00000320935
ENST00000317370
P14672 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 4
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005771 [multivesicular body]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0005975 [carbohydrate metabolic process]
GO:0008645 [hexose transport]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0010021 [amylopectin biosynthetic process]
GO:0012505 [endomembrane system]
GO:0012506 [vesicle membrane]
GO:0015758 [glucose transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0022891 [substrate-specific transmembrane transporter activity]
GO:0030136 [clathrin-coated vesicle]
GO:0030140 [trans-Golgi network transport vesicle]
GO:0030315 [T-tubule]
GO:0031982 [vesicle]
GO:0032593 [insulin-responsive compartment]
GO:0032869 [cellular response to insulin stimulus]
GO:0035428 [hexose transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042593 [glucose homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0045471 [response to ethanol]
GO:0046323 [glucose import]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050873 [brown fat cell differentiation]
GO:0055056 [D-glucose transmembrane transporter activity]
GO:0055085 [transmembrane transport]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071456 [cellular response to hypoxia]
GO:0071470 [cellular response to osmotic stress]
GO:1904659 [glucose transmembrane transport]
Show all
 509 aa
54.8 kDa 		No >9
SLC2A4-003
ENSP00000459864
ENST00000571308
I3L2R4 [Direct mapping]
Solute carrier family 2 (Facilitated glucose transporter), member 4, isoform CRA_b; Solute carrier family 2, facilitated glucose transporter member 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0022891 [substrate-specific transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
GO:1904659 [glucose transmembrane transport]
Show all
 461 aa
49 kDa 		No >9
SLC2A4-004
ENSP00000396887
ENST00000424875
F5H081 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0022891 [substrate-specific transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0055085 [transmembrane transport]
GO:1904659 [glucose transmembrane transport]
Show all
 451 aa
48 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.