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ADO

GENERAL INFORMATION

Gene name

 ADO

Gene description

 2-aminoethanethiol (cysteamine) dioxygenase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Extracellular positivity and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA039194 , HPA040437
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039194
HPA040437

GENE INFORMATION

Gene name

 ADO (HGNC Symbol)

Synonyms

 C10orf22, FLJ14547

Description

 2-aminoethanethiol (cysteamine) dioxygenase (HGNC Symbol)

Entrez gene summary

 Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 q21.3

Chromosome location (bp)

 62804857 - 62808483

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181915 (version 83.38)

Entrez gene

 84890

UniProt

 Q96SZ5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96SZ5

Antibodypedia

 ADO antibodies

PROTEIN BROWSER
ADO-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADO-001
ENSP00000362888
ENST00000373783
Q96SZ5 [Direct mapping]
2-aminoethanethiol dioxygenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen]
GO:0046872 [metal ion binding]
GO:0047800 [cysteamine dioxygenase activity]
GO:0055114 [oxidation-reduction process]
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 270 aa
29.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.