Expression of COA4 in cancer - Summary - The Human Protein Atlas

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COA4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COA4
Gene description	Cytochrome c oxidase assembly factor 4 homolog
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040126
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040126

GENE INFORMATION
Gene name	COA4 (HGNC Symbol)
Synonyms	CHCHD8, CMC3, E2IG2
Description	Cytochrome c oxidase assembly factor 4 homolog (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	73872667 - 73876988
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181924 (version 83.38)
Entrez gene	51287
UniProt	Q9NYJ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYJ1
Antibodypedia	COA4 antibodies

PROTEIN BROWSER

COA4-001	COA4-002	COA4-004	COA4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COA4-001 ENSP00000347919 ENST00000355693	Q9NYJ1 [Direct mapping] Cytochrome c oxidase assembly factor 4 homolog, mitochondrial A0A024R5J6 [Target identity:100%; Query identity:100%] Coiled-coil-helix-coiled-coil-helix domain containing 8, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005758 [mitochondrial intermembrane space] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	87 aa 10.1 kDa	No	0
COA4-002 ENSP00000440756 ENST00000541455	Q9NYJ1 [Direct mapping] Cytochrome c oxidase assembly factor 4 homolog, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005758 [mitochondrial intermembrane space] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	96 aa 11.3 kDa	No	0
COA4-004 ENSP00000437772 ENST00000537289	Q9NYJ1 [Direct mapping] Cytochrome c oxidase assembly factor 4 homolog, mitochondrial A0A024R5J6 [Target identity:100%; Query identity:100%] Coiled-coil-helix-coiled-coil-helix domain containing 8, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005758 [mitochondrial intermembrane space] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	87 aa 10.1 kDa	No	0
COA4-005 ENSP00000443795 ENST00000545127	Q9NYJ1 [Direct mapping] Cytochrome c oxidase assembly factor 4 homolog, mitochondrial A0A024R5J6 [Target identity:100%; Query identity:100%] Coiled-coil-helix-coiled-coil-helix domain containing 8, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005758 [mitochondrial intermembrane space] GO:0033617 [mitochondrial respiratory chain complex IV assembly] Show all	87 aa 10.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.