Expression of CCDC149 in cancer - Summary - The Human Protein Atlas

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CCDC149

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC149
Gene description	Coiled-coil domain containing 149
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-87 MG)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA044158 , HPA047913
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA044158	HPA047913

GENE INFORMATION
Gene name	CCDC149 (HGNC Symbol)
Synonyms	DKFZp761B107
Description	Coiled-coil domain containing 149 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p15.2
Chromosome location (bp)	24806117 - 24980204
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000181982 (version 83.38)
Entrez gene	91050
UniProt	Q6ZUS6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZUS6
Antibodypedia	CCDC149 antibodies

PROTEIN BROWSER

CCDC149-001	CCDC149-002	CCDC149-005	CCDC149-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC149-001 ENSP00000425715 ENST00000504487	Q6ZUS6 [Direct mapping] Coiled-coil domain-containing protein 149 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		529 aa 59.3 kDa	No	0
CCDC149-002 ENSP00000374260 ENST00000389609	Q6ZUS6 [Direct mapping] Coiled-coil domain-containing protein 149 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		529 aa 59.2 kDa	Yes	0
CCDC149-005 ENSP00000427529 ENST00000502801	Q6ZUS6 [Direct mapping] Coiled-coil domain-containing protein 149 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 16.7 kDa	No	0
CCDC149-009 ENSP00000488929 ENST00000635206		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		540 aa 60.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.