Expression of PNMAL1 in cancer - Summary - The Human Protein Atlas

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PNMAL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PNMAL1
Gene description	Paraneoplastic Ma antigen family-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (K-562, LHCN-M2, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA012956
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012956

GENE INFORMATION
Gene name	PNMAL1 (HGNC Symbol)
Synonyms	FLJ10781, KIAA1183L
Description	Paraneoplastic Ma antigen family-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	46466491 - 46471563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182013 (version 83.38)
Entrez gene	55228
UniProt	Q86V59 (UniProt - Evidence at protein level)
neXtProt	NX_Q86V59
Antibodypedia	PNMAL1 antibodies

PROTEIN BROWSER

PNMAL1-001	PNMAL1-002	PNMAL1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNMAL1-001 ENSP00000318131 ENST00000313683	Q86V59 [Direct mapping] PNMA-like protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		439 aa 48.2 kDa	No	0
PNMAL1-002 ENSP00000410273 ENST00000438932	Q86V59 [Direct mapping] PNMA-like protein 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		378 aa 41.9 kDa	No	0
PNMAL1-005 ENSP00000473064 ENST00000602246	M0R388 [Direct mapping] PNMA-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.