Expression of TMEM259 in cancer - Summary - The Human Protein Atlas

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TMEM259

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM259
Gene description	Transmembrane protein 259
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA042669
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable) and endometrial cancer (favourable).
Stomach cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042669

GENE INFORMATION
Gene name	TMEM259 (HGNC Symbol)
Synonyms	ASBABP1, C19orf6, MBRL, MGC4022
Description	Transmembrane protein 259 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1009648 - 1021179
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182087 (version 83.38)
Entrez gene	91304
UniProt	Q4ZIN3 (UniProt - Evidence at protein level)
neXtProt	NX_Q4ZIN3
Antibodypedia	TMEM259 antibodies

PROTEIN BROWSER

TMEM259-001	TMEM259-002	TMEM259-007	TMEM259-008	TMEM259-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM259-001 ENSP00000349087 ENST00000356663	Q4ZIN3 [Direct mapping] Membralin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0034976 [response to endoplasmic reticulum stress] GO:1901215 [negative regulation of neuron death] GO:1904294 [positive regulation of ERAD pathway] Show all	620 aa 67.9 kDa	No	6
TMEM259-002 ENSP00000331423 ENST00000333175	Q4ZIN3 [Direct mapping] Membralin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	408 aa 46.4 kDa	No	3
TMEM259-007 ENSP00000476127 ENST00000586250	U3KQQ5 [Direct mapping] Membralin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.8 kDa	No	0
TMEM259-008 ENSP00000475354 ENST00000592590	U3KPY4 [Direct mapping] Membralin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	421 aa 46.5 kDa	No	3
TMEM259-014 ENSP00000475219 ENST00000586285	U3KPU1 [Direct mapping] Membralin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	209 aa 23.8 kDa	No	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.