Expression of TMEM30B in cancer - Summary - The Human Protein Atlas

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TMEM30B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM30B
Gene description	Transmembrane protein 30B
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, CAPAN-2, MCF7, RT4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA043162
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043162

GENE INFORMATION
Gene name	TMEM30B (HGNC Symbol)
Synonyms	CDC50B
Description	Transmembrane protein 30B (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q23.1
Chromosome location (bp)	61277370 - 61281840
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182107 (version 83.38)
Entrez gene	161291
UniProt	Q3MIR4 (UniProt - Evidence at protein level)
neXtProt	NX_Q3MIR4
Antibodypedia	TMEM30B antibodies

PROTEIN BROWSER

TMEM30B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM30B-001 ENSP00000450842 ENST00000555868	Q3MIR4 [Direct mapping] Cell cycle control protein 50B Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006869 [lipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070863 [positive regulation of protein exit from endoplasmic reticulum] Show all	351 aa 38.9 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.