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NOP10

GENERAL INFORMATION

Gene name

 NOP10

Gene description

 NOP10 ribonucleoprotein

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nucleolus expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA059198
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059198

GENE INFORMATION

Gene name

 NOP10 (HGNC Symbol)

Synonyms

 MGC70651, NOLA3, NOP10P

Description

 NOP10 ribonucleoprotein (HGNC Symbol)

Entrez gene summary

 This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q14

Chromosome location (bp)

 34341713 - 34343177

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182117 (version 83.38)

Entrez gene

 55505

UniProt

 Q9NPE3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPE3

Antibodypedia

 NOP10 antibodies

PROTEIN BROWSER
NOP10-001
NOP10-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOP10-001
ENSP00000332198
ENST00000328848
Q9NPE3 [Direct mapping]
H/ACA ribonucleoprotein complex subunit 3
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001522 [pseudouridine synthesis]
GO:0005515 [protein binding]
GO:0005697 [telomerase holoenzyme complex]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0006364 [rRNA processing]
GO:0007004 [telomere maintenance via telomerase]
GO:0030515 [snoRNA binding]
GO:0031429 [box H/ACA snoRNP complex]
GO:0042254 [ribosome biogenesis]
GO:0070034 [telomeric RNA binding]
GO:0072588 [box H/ACA RNP complex]
GO:0072589 [box H/ACA scaRNP complex]
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 64 aa
7.7 kDa 		No 0
NOP10-002
ENSP00000453475
ENST00000557912
H0YM60 [Direct mapping]
H/ACA ribonucleoprotein complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 36 aa
4.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.