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TSEN54

GENERAL INFORMATION

Gene name

 TSEN54

Gene description

 TSEN54 tRNA splicing endonuclease subunit

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Subcellular location is contradicted by limited external data.

Reliability score

 Uncertain based on 1 antibody.
HPA053097
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (favourable), stomach cancer (favourable) and urothelial cancer (favourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Stomach cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053097

GENE INFORMATION

Gene name

 TSEN54 (HGNC Symbol)

Synonyms

 SEN54, SEN54L

Description

 TSEN54 tRNA splicing endonuclease subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also implicated in pre-mRNA 3-prime end processing. Mutations in this gene result in pontocerebellar hypoplasia type 2.[provided by RefSeq, Oct 2009]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 75516060 - 75524739

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182173 (version 83.38)

Entrez gene

 283989

UniProt

 Q7Z6J9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z6J9

Antibodypedia

 TSEN54 antibodies

PROTEIN BROWSER
TSEN54-001
TSEN54-005
TSEN54-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSEN54-001
ENSP00000327487
ENST00000333213
Q7Z6J9 [Direct mapping]
tRNA-splicing endonuclease subunit Sen54
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006388 [tRNA splicing, via endonucleolytic cleavage and ligation]
GO:0006397 [mRNA processing]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
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 526 aa
58.8 kDa 		No 0
TSEN54-005
ENSP00000406559
ENST00000434205
E7EN92 [Direct mapping]
tRNA-splicing endonuclease subunit Sen54
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
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 72 aa
8.5 kDa 		No 0
TSEN54-012
ENSP00000438169
ENST00000545228
J9JIH8 [Direct mapping]
tRNA-splicing endonuclease subunit Sen54
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000213 [tRNA-intron endonuclease activity]
GO:0000214 [tRNA-intron endonuclease complex]
GO:0000379 [tRNA-type intron splice site recognition and cleavage]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 259 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.