Expression of LDOC1 in cancer - Summary - The Human Protein Atlas

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LDOC1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LDOC1
Gene description	Leucine zipper, down-regulated in cancer 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (MCF7, PC-3)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and/or cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051768
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051768

GENE INFORMATION
Gene name	LDOC1 (HGNC Symbol)
Synonyms	BCUR1, Mar7, Mart7
Description	Leucine zipper, down-regulated in cancer 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q27.1
Chromosome location (bp)	141175745 - 141177125
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182195 (version 83.38)
Entrez gene	23641
UniProt	O95751 (UniProt - Evidence at protein level)
neXtProt	NX_O95751
Antibodypedia	LDOC1 antibodies

PROTEIN BROWSER

LDOC1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LDOC1-001 ENSP00000359557 ENST00000370526	O95751 [Direct mapping] Protein LDOC1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0008285 [negative regulation of cell proliferation] Show all	146 aa 17 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.