Expression of ATP6AP2 in cancer - Summary - The Human Protein Atlas

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ATP6AP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP6AP2
Gene description	ATPase, H+ transporting, lysosomal accessory protein 2
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA003156
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003156

GENE INFORMATION
Gene name	ATP6AP2 (HGNC Symbol)
Synonyms	APT6M8-9, ATP6IP2, ATP6M8-9, M8-9, PRR, RENR
Description	ATPase, H+ transporting, lysosomal accessory protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.4
Chromosome location (bp)	40580908 - 40606637
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182220 (version 83.38)
Entrez gene	10159
UniProt	O75787 (UniProt - Evidence at protein level)
neXtProt	NX_O75787
Antibodypedia	ATP6AP2 antibodies

PROTEIN BROWSER

ATP6AP2-001	ATP6AP2-004	ATP6AP2-006	ATP6AP2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6AP2-001 ENSP00000411317 ENST00000447485	H7C3E1 [Direct mapping] Renin receptor Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0016021 [integral component of membrane] Show all	259 aa 28.7 kDa	No	0
ATP6AP2-004 ENSP00000367697 ENST00000378438	O75787 [Direct mapping] Renin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002003 [angiotensin maturation] GO:0004190 [aspartic-type endopeptidase activity] GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0021903 [rostrocaudal neural tube patterning] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0032914 [positive regulation of transforming growth factor beta1 production] GO:0043005 [neuron projection] GO:0043408 [regulation of MAPK cascade] GO:0044267 [cellular protein metabolic process] GO:0044297 [cell body] GO:0048069 [eye pigmentation] GO:0060323 [head morphogenesis] GO:0070062 [extracellular exosome] Show all	350 aa 39 kDa	Yes	1
ATP6AP2-006 ENSP00000410105 ENST00000423649	H0Y750 [Direct mapping] Renin receptor Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004872 [receptor activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	243 aa 26.5 kDa	Yes	0
ATP6AP2-007 ENSP00000403969 ENST00000436783	H7C240 [Direct mapping] Renin receptor Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0016021 [integral component of membrane] Show all	203 aa 22.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.