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Gene name

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Chromosome

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Reliability

Reliability

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Validation

Method

Validation

Method

Validation

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Cancer

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Tissue

Detectable

Cell line

Detectable

Cancer

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FAM153B
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FAM153B

Gene description

Family with sequence similarity 153, member B

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (U-2 OS)
HPA (normal tissue):Tissue enhanced (ovary, testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

Uncertain based on 5 antibodies.
HPA042585 , HPA044022 , HPA046691 , HPA052337 , HPA055498
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA042585
HPA044022
HPA046691
HPA052337
HPA055498

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most cancer tissues showed moderate cytoplasmic and nuclear positivity. Hepatocellular carcinomas and occasional colorectal cancers displayed strong immunoreactivity. Many lymphomas and renal cell carcinomas were weakly stained or negative.

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Cancer tissues showed weak to moderate cytoplasmic positivity with additional nuclear staining in several cases. Occasional cases of gliomas and a single case each of colorectal, endometrial, renal, stomach and pancreatic cancers displayed strong positivity. Lymphomas were negative.

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

A majority of cancer tissues showed weak to moderate cytoplasmic and/or nuclear positivity. Few cases of cholangiocarcinomas exhibited strong immunoreactivity. Lymphomas, carcinoid and testicular cancers were in general negative.

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most cancer tissues showed weak to moderate cytoplasmic positivity with additional membranous or nuclear staining in few cases. Lymphomas along with several lung, cervical, urothelial and renal cancers were negative.

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

A single case of duct carcinoma of breast showed moderate nuclear staining. Occasional cases of cervix cancers exhibited moderate to strong positivity. Few cases of endometrial cancers and occasional cases of ovarian cancers displayed moderate cytoplasmic and nuclear immunoreactivity. A single case of seminoma showed moderate cytoplasmic staining. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

FAM153B

Synonyms

Description

Family with sequence similarity 153, member B (HGNC Symbol)

Entrez gene summary

Chromosome

5

Cytoband

q35.2

Chromosome location (bp)

176060689 - 176132258

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000182230 (version 83.38)

Entrez gene

202134

UniProt

P0C7A2 (UniProt - Evidence at transcript level)

neXtProt

NX_P0C7A2

Antibodypedia

FAM153B antibodies

PROTEIN BROWSER

FAM153B-003
FAM153B-006
FAM153B-008
FAM153B-022
FAM153B-201
FAM153B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FAM153B-003
ENSP00000427684
ENST00000515817
D6RF84 [Direct mapping]
Protein FAM153B
Show all
Predicted intracellular proteins
Show all
310 aa
34.7 kDa
No 0
FAM153B-006
ENSP00000453424
ENST00000510151
D6RF84 [Direct mapping]
Protein FAM153B
Show all
Predicted intracellular proteins
Show all
310 aa
34.7 kDa
No 0
FAM153B-008
ENSP00000453712
ENST00000512862
H0YMR7 [Direct mapping]
Protein FAM153B
Show all
Predicted intracellular proteins
Show all
144 aa
16.6 kDa
No 0
FAM153B-022
ENSP00000453011
ENST00000503724
H0YL08 [Direct mapping]
Protein FAM153B
Show all
Predicted intracellular proteins
Show all
133 aa
14.9 kDa
No 0
FAM153B-201
ENSP00000253490
ENST00000253490
P0C7A2 [Direct mapping]
Protein FAM153B
Show all
Predicted intracellular proteins
Show all
387 aa
43.6 kDa
No 0
FAM153B-202
ENSP00000481297
ENST00000611539
H0YMR7 [Direct mapping]
Protein FAM153B
Show all
Predicted intracellular proteins
Show all
144 aa
16.6 kDa
No 0

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