Expression of BACE2 in cancer - Summary - The Human Protein Atlas

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BACE2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BACE2
Gene description	Beta-site APP-cleaving enzyme 2
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SK-BR-3, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, including neurons.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB008975
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and glioma (unfavourable).
Cervical cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB008975

GENE INFORMATION
Gene name	BACE2 (HGNC Symbol)
Synonyms	AEPLC, ALP56, CEAP1, DRAP
Description	Beta-site APP-cleaving enzyme 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	21
Cytoband
Chromosome location (bp)	41167801 - 41282518
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182240 (version 83.38)
Entrez gene	25825
UniProt	Q9Y5Z0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Z0
Antibodypedia	BACE2 antibodies

PROTEIN BROWSER

BACE2-001	BACE2-002	BACE2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BACE2-001 ENSP00000332979 ENST00000330333	Q9Y5Z0 [Direct mapping] Beta-secretase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0030163 [protein catabolic process] GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process] GO:0050435 [beta-amyloid metabolic process] Show all	518 aa 56.2 kDa	Yes	1
BACE2-002 ENSP00000327528 ENST00000347667	Q9Y5Z0 [Direct mapping] Beta-secretase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0030163 [protein catabolic process] GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process] GO:0050435 [beta-amyloid metabolic process] Show all	468 aa 50.3 kDa	Yes	1
BACE2-003 ENSP00000333854 ENST00000328735	Q9Y5Z0 [Direct mapping] Beta-secretase 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0005768 [endosome] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0030163 [protein catabolic process] GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process] GO:0050435 [beta-amyloid metabolic process] Show all	396 aa 43 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.