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IZUMO1

GENERAL INFORMATION

Gene name

 IZUMO1

Gene description

 Izumo sperm-egg fusion 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic expression in spermatids.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA038104
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 IZUMO1 (HGNC Symbol)

Synonyms

 IZUMO, MGC34799, OBF

Description

 Izumo sperm-egg fusion 1 (HGNC Symbol)

Entrez gene summary

 The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 48740852 - 48746909

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182264 (version 83.38)

Entrez gene

 284359

UniProt

 Q8IYV9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IYV9

Antibodypedia

 IZUMO1 antibodies

PROTEIN BROWSER
IZUMO1-001
IZUMO1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IZUMO1-001
ENSP00000327786
ENST00000332955
Q8IYV9 [Direct mapping]
Izumo sperm-egg fusion protein 1
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Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0001669 [acrosomal vesicle]
GO:0002080 [acrosomal membrane]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007338 [single fertilization]
GO:0007342 [fusion of sperm to egg plasma membrane]
GO:0016021 [integral component of membrane]
GO:0032504 [multicellular organism reproduction]
GO:0035036 [sperm-egg recognition]
GO:0042803 [protein homodimerization activity]
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 350 aa
38.9 kDa 		Yes 1
IZUMO1-006
ENSP00000471134
ENST00000602105
M0R0B8 [Direct mapping]
Izumo sperm-egg fusion protein 1
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Predicted intracellular proteins
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 15 aa
1.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.