Expression of B4GALNT4 in cancer - Summary

GENERAL INFORMATION
Gene name	B4GALNT4
Gene description	Beta-1,4-N-acetyl-galactosaminyl transferase 4
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, ovary)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissues, most distinct in a subset of lymphoid cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA053126
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA053126

GENE INFORMATION
Gene name	B4GALNT4 (HGNC Symbol)
Synonyms	FLJ25045, NGalNAc-T1
Description	Beta-1,4-N-acetyl-galactosaminyl transferase 4 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	369796 - 382116
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182272 (version 83.38)
Entrez gene	338707
UniProt	Q76KP1 (UniProt - Evidence at protein level)
neXtProt	NX_Q76KP1
Antibodypedia	B4GALNT4 antibodies

PROTEIN BROWSER

B4GALNT4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B4GALNT4-001 ENSP00000328277 ENST00000329962	Q76KP1 [Direct mapping] N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0008152 [metabolic process] GO:0008376 [acetylgalactosaminyltransferase activity] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] GO:0033842 [N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity] Show all	1039 aa 116.5 kDa	Yes	0