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AP1S2

GENERAL INFORMATION

Gene name

 AP1S2

Gene description

 Adaptor-related protein complex 1, sigma 2 subunit

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (epididymis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including epididymis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA049894 , HPA060945
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable) and breast cancer (favourable).
Ovarian cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049894
HPA060945

GENE INFORMATION

Gene name

 AP1S2 (HGNC Symbol)

Synonyms

 MRX59, MRXS5, PGS, SIGMA1B

Description

 Adaptor-related protein complex 1, sigma 2 subunit (HGNC Symbol)

Entrez gene summary

 Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 15825806 - 15855014

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182287 (version 83.38)

Entrez gene

 8905

UniProt

 P56377 (UniProt - Evidence at protein level)

neXtProt

 NX_P56377

Antibodypedia

 AP1S2 antibodies

PROTEIN BROWSER
AP1S2-001
AP1S2-002
AP1S2-003
AP1S2-004
AP1S2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP1S2-001
ENSP00000328789
ENST00000329235
P56377 [Direct mapping]
AP-1 complex subunit sigma-2
Q549M9 [Target identity:100%; Query identity:100%]
Adaptor-related protein complex 1, sigma 2 subunit, isoform CRA_e; Clathrin-associated protein 19
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030117 [membrane coat]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
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 157 aa
18.6 kDa 		No 0
AP1S2-002
ENSP00000403498
ENST00000452376
H0Y673 [Direct mapping]
AP-1 complex subunit sigma-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
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 153 aa
18 kDa 		No 0
AP1S2-003
ENSP00000369645
ENST00000380291
A6NH01 [Direct mapping]
AP-1 complex subunit sigma-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
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 160 aa
19.1 kDa 		No 0
AP1S2-004
ENSP00000389474
ENST00000450644
H7BZG6 [Direct mapping]
AP-1 complex subunit sigma-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
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 146 aa
17.4 kDa 		No 0
AP1S2-201
ENSP00000444957
ENST00000545766
F6SFB5 [Direct mapping]
AP-1 complex subunit sigma-2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008542 [visual learning]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
GO:0036465 [synaptic vesicle recycling]
GO:0045444 [fat cell differentiation]
GO:0050885 [neuromuscular process controlling balance]
GO:0060612 [adipose tissue development]
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 160 aa
18.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.