Expression of LIPF in cancer - Summary - The Human Protein Atlas

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LIPF

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LIPF
Gene description	Lipase, gastric
Protein class	Enzymes FDA approved drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (stomach cancer)
HPA (cell line):	Cell line enhanced (HMC-1, MOLT-4, NTERA-2, THP-1, U-2 OS, U-266/70)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA045930
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045930

GENE INFORMATION
Gene name	LIPF (HGNC Symbol)
Synonyms	HGL, HLAL
Description	Lipase, gastric (HGNC Symbol)
Entrez gene summary	This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Chromosome	10
Cytoband	q23.31
Chromosome location (bp)	88664441 - 88678814
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182333 (version 83.38)
Entrez gene	8513
UniProt	P07098 (UniProt - Evidence at protein level)
neXtProt	NX_P07098
Antibodypedia	LIPF antibodies

PROTEIN BROWSER

LIPF-001	LIPF-002	LIPF-004	LIPF-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIPF-001 ENSP00000238983 ENST00000238983	P07098 [Direct mapping] Gastric triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0006641 [triglyceride metabolic process] GO:0008289 [lipid binding] GO:0016042 [lipid catabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	398 aa 45.2 kDa	Yes	0
LIPF-002 ENSP00000348101 ENST00000355843	P07098 [Direct mapping] Gastric triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0006641 [triglyceride metabolic process] GO:0008289 [lipid binding] GO:0016042 [lipid catabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	375 aa 42.8 kDa	Yes	0
LIPF-004 ENSP00000377900 ENST00000394375	P07098 [Direct mapping] Gastric triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0005739 [mitochondrion] GO:0006108 [malate metabolic process] GO:0006629 [lipid metabolic process] GO:0006641 [triglyceride metabolic process] GO:0008289 [lipid binding] GO:0016042 [lipid catabolic process] GO:0016615 [malate dehydrogenase activity] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0055114 [oxidation-reduction process] Show all	408 aa 46.4 kDa	Yes	0
LIPF-006 ENSP00000477140 ENST00000608620	P07098 [Direct mapping] Gastric triacylglycerol lipase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004806 [triglyceride lipase activity] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0006641 [triglyceride metabolic process] GO:0008289 [lipid binding] GO:0016042 [lipid catabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	365 aa 41.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.