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DAOA

GENERAL INFORMATION

Gene name

 DAOA

Gene description

 D-amino acid oxidase activator

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Approved based on 1 antibody.
HPA053114
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
HPA053114

GENE INFORMATION

Gene name

 DAOA (HGNC Symbol)

Synonyms

 G72

Description

 D-amino acid oxidase activator (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

Chromosome

 13

Cytoband

 q33.2

Chromosome location (bp)

 105465867 - 105491034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182346 (version 83.38)

Entrez gene

 267012

UniProt

 P59103 (UniProt - Evidence at protein level)

neXtProt

 NX_P59103

Antibodypedia

 DAOA antibodies

PROTEIN BROWSER
DAOA-005
DAOA-006
DAOA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAOA-005
ENSP00000365103
ENST00000375936
P59103 [Direct mapping]
D-amino acid oxidase activator
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Predicted intracellular proteins
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GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0008047 [enzyme activator activity]
GO:0019899 [enzyme binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:1900758 [negative regulation of D-amino-acid oxidase activity]
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 153 aa
18.1 kDa 		No 0
DAOA-006
ENSP00000329951
ENST00000329625
P59103 [Direct mapping]
D-amino acid oxidase activator
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Predicted intracellular proteins
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GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0008047 [enzyme activator activity]
GO:0019899 [enzyme binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:1900758 [negative regulation of D-amino-acid oxidase activity]
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 82 aa
9.8 kDa 		No 0
DAOA-201
ENSP00000483757
ENST00000618629
P59103 [Direct mapping]
D-amino acid oxidase activator
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Predicted intracellular proteins
Show all
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0008047 [enzyme activator activity]
GO:0019899 [enzyme binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:1900758 [negative regulation of D-amino-acid oxidase activity]
Show all
 153 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.