Expression of PLCXD1 in cancer - Summary - The Human Protein Atlas

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PLCXD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLCXD1
Gene description	Phosphatidylinositol-specific phospholipase C, X domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA007721
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), head and neck cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007721

GENE INFORMATION
Gene name	PLCXD1 (HGNC Symbol)
Synonyms	FLJ11323
Description	Phosphatidylinositol-specific phospholipase C, X domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	276322 - 303356
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182378 (version 83.38)
Entrez gene	55344
UniProt	Q9NUJ7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NUJ7
Antibodypedia	PLCXD1 antibodies

PROTEIN BROWSER

PLCXD1-001	PLCXD1-002	PLCXD1-003	PLCXD1-004	PLCXD1-005	PLCXD1-006	PLCXD1-007	PLCXD1-008	PLCXD1-010	PLCXD1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLCXD1-001 ENSP00000381976 ENST00000399012	Q9NUJ7 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	323 aa 36.7 kDa	No	0
PLCXD1-002 ENSP00000371073 ENST00000381657	Q9NUJ7 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	323 aa 36.7 kDa	No	0
PLCXD1-003 ENSP00000408558 ENST00000443019	A0A0A0MSZ3 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	74 aa 8.3 kDa	No	0
PLCXD1-004 ENSP00000414181 ENST00000448477	A0A0A0MT41 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	124 aa 14.1 kDa	No	0
PLCXD1-005 ENSP00000412018 ENST00000445062	A0A0A0MT29 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	88 aa 10 kDa	No	0
PLCXD1-006 ENSP00000400904 ENST00000429181	K7EIC3 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	60 aa 6.7 kDa	No	0
PLCXD1-007 ENSP00000399510 ENST00000415337	X6RFG1 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	178 aa 20.3 kDa	No	0
PLCXD1-008 ENSP00000405307 ENST00000447472	C9JP92 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	174 aa 19.9 kDa	No	0
PLCXD1-010 ENSP00000394848 ENST00000430923	C9JP92 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	174 aa 19.9 kDa	No	0
PLCXD1-201 ENSP00000371079 ENST00000381663	Q9NUJ7 [Direct mapping] PI-PLC X domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0008081 [phosphoric diester hydrolase activity] Show all	323 aa 36.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.