Expression of NPLOC4 in cancer - Summary - The Human Protein Atlas

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NPLOC4

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPLOC4
Gene description	NPL4 homolog, ubiquitin recognition factor
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA021560 , HPA023295
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021560	HPA023295

GENE INFORMATION
Gene name	NPLOC4 (HGNC Symbol)
Synonyms	FLJ20657, KIAA1499, NPL4
Description	NPL4 homolog, ubiquitin recognition factor (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81556887 - 81648465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182446 (version 83.38)
Entrez gene	55666
UniProt	Q8TAT6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAT6
Antibodypedia	NPLOC4 antibodies

PROTEIN BROWSER

NPLOC4-001	NPLOC4-002	NPLOC4-004	NPLOC4-005	NPLOC4-008	NPLOC4-016	NPLOC4-017	NPLOC4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPLOC4-001 ENSP00000331487 ENST00000331134	Q8TAT6 [Direct mapping] Nuclear protein localization protein 4 homolog A0A024R8R4 [Target identity:100%; Query identity:100%] Nuclear protein localization 4 homolog (S. cerevisiae), isoform CRA_a Show all	Transporters Primary Active Transporters Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007030 [Golgi organization] GO:0008270 [zinc ion binding] GO:0019985 [translesion synthesis] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0031625 [ubiquitin protein ligase binding] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0036501 [UFD1-NPL4 complex] GO:0042175 [nuclear outer membrane-endoplasmic reticulum membrane network] GO:0043130 [ubiquitin binding] GO:0070987 [error-free translesion synthesis] Show all	608 aa 68.1 kDa	No	0
NPLOC4-002 ENSP00000363879 ENST00000374747	Q8TAT6 [Direct mapping] Nuclear protein localization protein 4 homolog Show all	Transporters Primary Active Transporters Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007030 [Golgi organization] GO:0008270 [zinc ion binding] GO:0019985 [translesion synthesis] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030970 [retrograde protein transport, ER to cytosol] GO:0031625 [ubiquitin protein ligase binding] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0036501 [UFD1-NPL4 complex] GO:0042175 [nuclear outer membrane-endoplasmic reticulum membrane network] GO:0043130 [ubiquitin binding] GO:0070987 [error-free translesion synthesis] Show all	617 aa 69.5 kDa	No	0
NPLOC4-004 ENSP00000467400 ENST00000572760	K7EJN1 [Direct mapping] Nuclear protein localization protein 4 homolog Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0043130 [ubiquitin binding] Show all	56 aa 5.5 kDa	No	0
NPLOC4-005 ENSP00000465247 ENST00000573876	K7EJN1 [Direct mapping] Nuclear protein localization protein 4 homolog Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0043130 [ubiquitin binding] Show all	56 aa 5.5 kDa	No	0
NPLOC4-008 ENSP00000458384 ENST00000572824	I3L0W3 [Direct mapping] Nuclear protein localization protein 4 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0043130 [ubiquitin binding] Show all	172 aa 18.5 kDa	No	0
NPLOC4-016 ENSP00000459457 ENST00000573519	I3L281 [Direct mapping] Nuclear protein localization protein 4 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0043130 [ubiquitin binding] Show all	145 aa 16.1 kDa	No	0
NPLOC4-017 ENSP00000460465 ENST00000571714	I3L3I1 [Direct mapping] Nuclear protein localization protein 4 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0043130 [ubiquitin binding] Show all	182 aa 20 kDa	No	0
NPLOC4-201 ENSP00000486640 ENST00000625705	A0A0D9SFI9 [Direct mapping] Nuclear protein localization protein 4 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0043130 [ubiquitin binding] Show all	134 aa 14.9 kDa	No	0

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