Cell atlas - KCNK4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

KCNK4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	KCNK4
Gene description	Potassium channel, two pore domain subfamily K, member 4
Protein class	Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	KCNK4 (HGNC Symbol)
Synonyms	K2p4.1, TRAAK
Description	Potassium channel, two pore domain subfamily K, member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64291302 - 64300031
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182450 (version 83.38)
Entrez gene	50801
UniProt	Q9NYG8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYG8
Antibodypedia	KCNK4 antibodies

PROTEIN BROWSER

KCNK4-001	KCNK4-002	KCNK4-003	KCNK4-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK4-001 ENSP00000402797 ENST00000422670	Q9NYG8 [Direct mapping] Potassium channel subfamily K member 4 A0A024R5C7 [Target identity:100%; Query identity:100%] HCG1810791, isoform CRA_b Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0019233 [sensory perception of pain] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034705 [potassium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0050951 [sensory perception of temperature stimulus] GO:0050976 [detection of mechanical stimulus involved in sensory perception of touch] GO:0071260 [cellular response to mechanical stimulus] GO:0071398 [cellular response to fatty acid] GO:0071469 [cellular response to alkaline pH] GO:0071502 [cellular response to temperature stimulus] GO:0071805 [potassium ion transmembrane transport] GO:0097604 [temperature-gated cation channel activity] GO:0098782 [mechanically-gated potassium channel activity] Show all	393 aa 42.7 kDa	Yes	5
KCNK4-002 ENSP00000444948 ENST00000539216	Q9NYG8 [Direct mapping] Potassium channel subfamily K member 4 A0A024R5C7 [Target identity:100%; Query identity:100%] HCG1810791, isoform CRA_b Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007613 [memory] GO:0019233 [sensory perception of pain] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034705 [potassium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0050951 [sensory perception of temperature stimulus] GO:0050976 [detection of mechanical stimulus involved in sensory perception of touch] GO:0071260 [cellular response to mechanical stimulus] GO:0071398 [cellular response to fatty acid] GO:0071469 [cellular response to alkaline pH] GO:0071502 [cellular response to temperature stimulus] GO:0071805 [potassium ion transmembrane transport] GO:0097604 [temperature-gated cation channel activity] GO:0098782 [mechanically-gated potassium channel activity] Show all	393 aa 42.7 kDa	Yes	5
KCNK4-003 ENSP00000378033 ENST00000394525	Q9NYG8 [Direct mapping] Potassium channel subfamily K member 4 A0A024R5C7 [Target identity:100%; Query identity:100%] HCG1810791, isoform CRA_b Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0019233 [sensory perception of pain] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034705 [potassium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0050951 [sensory perception of temperature stimulus] GO:0050976 [detection of mechanical stimulus involved in sensory perception of touch] GO:0071260 [cellular response to mechanical stimulus] GO:0071398 [cellular response to fatty acid] GO:0071469 [cellular response to alkaline pH] GO:0071502 [cellular response to temperature stimulus] GO:0071805 [potassium ion transmembrane transport] GO:0097604 [temperature-gated cation channel activity] GO:0098782 [mechanically-gated potassium channel activity] Show all	393 aa 42.7 kDa	Yes	5
KCNK4-006 ENSP00000446454 ENST00000538767	F5GYE0 [Direct mapping] Potassium channel subfamily K member 4 Show all	Predicted intracellular proteins Show all	GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	310 aa 32.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.