Expression of CAPN12 in cancer - Summary - The Human Protein Atlas

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CAPN12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CAPN12
Gene description	Calpain 12
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Tissue enriched (gallbladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA043492 , HPA053322
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043492	HPA053322

GENE INFORMATION
Gene name	CAPN12
Synonyms
Description	Calpain 12 (HGNC Symbol)
Entrez gene summary	The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38730187 - 38769904
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182472 (version 83.38)
Entrez gene	147968
UniProt	Q6ZSI9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZSI9
Antibodypedia	CAPN12 antibodies

PROTEIN BROWSER

CAPN12-001	CAPN12-002	CAPN12-006	CAPN12-010	CAPN12-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPN12-001 ENSP00000331636 ENST00000328867	Q6ZSI9 [Direct mapping] Calpain-12 Show all	Enzymes Peptidases Cysteine-type peptidases SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	719 aa 81 kDa	No	0
CAPN12-002 ENSP00000473156 ENST00000601953	M0R3D7 [Direct mapping] Calpain-12 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	570 aa 64.5 kDa	No	0
CAPN12-006 ENSP00000470233 ENST00000598684	M0QZ20 [Direct mapping] Calpain-12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	179 aa 20.2 kDa	No	0
CAPN12-010 ENSP00000471007 ENST00000595177	M0R052 [Direct mapping] Calpain-12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	104 aa 11.7 kDa	No	0
CAPN12-011 ENSP00000470760 ENST00000597987	M0QZT6 [Direct mapping] Calpain-12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	105 aa 12 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.