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GLRX5

GENERAL INFORMATION

Gene name

 GLRX5

Gene description

 Glutaredoxin 5

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA042465
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042465

GENE INFORMATION

Gene name

 GLRX5 (HGNC Symbol)

Synonyms

 C14orf87, GRX5, PR01238

Description

 Glutaredoxin 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]

Chromosome

 14

Cytoband

 q32.13

Chromosome location (bp)

 95533503 - 95544724

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182512 (version 83.38)

Entrez gene

 51218

UniProt

 Q86SX6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86SX6

Antibodypedia

 GLRX5 antibodies

PROTEIN BROWSER
GLRX5-001
GLRX5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLRX5-001
ENSP00000328570
ENST00000331334
Q86SX6 [Direct mapping]
Glutaredoxin-related protein 5, mitochondrial
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0030097 [hemopoiesis]
GO:0030425 [dendrite]
GO:0043025 [neuronal cell body]
GO:0045454 [cell redox homeostasis]
GO:0046872 [metal ion binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
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 157 aa
16.6 kDa 		No 0
GLRX5-002
ENSP00000451800
ENST00000557731
H0YJM6 [Direct mapping]
Glutaredoxin-related protein 5, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 137 aa
15.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.