Expression of RNASE10 in cancer - Summary - The Human Protein Atlas

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RNASE10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNASE10
Gene description	Ribonuclease, RNase A family, 10 (non-active)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (head and neck cancer, testis cancer)
HPA (cell line):	Cell line enhanced (SiHa, U-2 OS)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA052593
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (head and neck cancer, testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052593

GENE INFORMATION
Gene name	RNASE10 (HGNC Symbol)
Synonyms	RAH1, RNASE9
Description	Ribonuclease, RNase A family, 10 (non-active) (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20505537 - 20511169
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000182545 (version 83.38)
Entrez gene	338879
UniProt	Q5GAN6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5GAN6
Antibodypedia	RNASE10 antibodies

PROTEIN BROWSER

RNASE10-001	RNASE10-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASE10-001 ENSP00000333358 ENST00000328444	Q5GAN6 [Direct mapping] Inactive ribonuclease-like protein 10 W0UTC4 [Target identity:100%; Query identity:100%] Ribonuclease A H1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003382 [epithelial cell morphogenesis] GO:0003676 [nucleic acid binding] GO:0005576 [extracellular region] GO:0007338 [single fertilization] GO:0008584 [male gonad development] GO:0022409 [positive regulation of cell-cell adhesion] GO:0034113 [heterotypic cell-cell adhesion] GO:0072520 [seminiferous tubule development] GO:0080154 [regulation of fertilization] GO:1902093 [positive regulation of sperm motility] Show all	216 aa 24 kDa	Yes	0
RNASE10-002 ENSP00000392996 ENST00000430083	Q5GAN6 [Direct mapping] Inactive ribonuclease-like protein 10 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005576 [extracellular region] GO:0022409 [positive regulation of cell-cell adhesion] GO:0034113 [heterotypic cell-cell adhesion] GO:0080154 [regulation of fertilization] GO:1902093 [positive regulation of sperm motility] Show all	244 aa 27 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.