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SPNS3

GENERAL INFORMATION

Gene name

 SPNS3

Gene description

 Spinster homolog 3 (Drosophila)

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HL-60, MOLT-4, NB-4, THP-1, U-698, U-937)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA023928
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023928

GENE INFORMATION

Gene name

 SPNS3 (HGNC Symbol)

Synonyms

 MGC29671

Description

 Spinster homolog 3 (Drosophila) (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 4433688 - 4488208

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182557 (version 83.38)

Entrez gene

 201305

UniProt

 Q6ZMD2 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6ZMD2

Antibodypedia

 SPNS3 antibodies

PROTEIN BROWSER
SPNS3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPNS3-001
ENSP00000347721
ENST00000355530
Q6ZMD2 [Direct mapping]
Protein spinster homolog 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0003376 [sphingosine-1-phosphate signaling pathway]
GO:0005765 [lysosomal membrane]
GO:0006869 [lipid transport]
GO:0016021 [integral component of membrane]
GO:0031982 [vesicle]
GO:0040011 [locomotion]
GO:0046624 [sphingolipid transporter activity]
GO:0055085 [transmembrane transport]
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 512 aa
54.8 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.