Expression of CLEC4G in cancer - Summary - The Human Protein Atlas

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CLEC4G

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLEC4G
Gene description	C-type lectin domain family 4, member G
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (adipose tissue, liver, lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High expression in liver sinusoids and endothelial cells in lymph node.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA014044 , CAB003789
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014044	CAB003789

GENE INFORMATION
Gene name	CLEC4G (HGNC Symbol)
Synonyms	LSECtin, UNQ431
Description	C-type lectin domain family 4, member G (HGNC Symbol)
Entrez gene summary	This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7728957 - 7733906
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182566 (version 83.38)
Entrez gene	339390
UniProt	Q6UXB4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXB4
Antibodypedia	CLEC4G antibodies

PROTEIN BROWSER

CLEC4G-001	CLEC4G-002	CLEC4G-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC4G-001 ENSP00000327599 ENST00000328853	Q6UXB4 [Direct mapping] C-type lectin domain family 4 member G Q08G24 [Target identity:100%; Query identity:100%] LSECtin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001618 [virus receptor activity] GO:0002710 [negative regulation of T cell mediated immunity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030247 [polysaccharide binding] GO:0042130 [negative regulation of T cell proliferation] GO:0046718 [viral entry into host cell] Show all	293 aa 32.6 kDa	No	1
CLEC4G-002 ENSP00000472374 ENST00000599020	M0R277 [Direct mapping] C-type lectin domain family 4 member G Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	149 aa 15.8 kDa	No	1
CLEC4G-201 ENSP00000483109 ENST00000620128	A0A087X056 [Direct mapping] C-type lectin domain family 4 member G Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		252 aa 27.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.