Cell atlas - EPGN - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EPGN
Gene description	Epithelial mitogen
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nuclear membrane & cytosol.
RNA cell category	Group enriched (hTCEpi, U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Nuclear membrane (approved), Cytosol (approved)
Mouse	Localized to the Nuclear membrane in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA014369
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (hTCEpi, U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nuclear membrane & cytosol.

Main location

Nucleus (approved)

Additional location

Nuclear membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA014369	HeLa	Nucleus
		Nuclear membrane
		Cytosol
HPA014369	U-2 OS	Nucleus
HPA014369	U-2 OS	Nuclear membrane
HPA014369	U-251 MG	Nucleus
HPA014369	U-251 MG	Nuclear membrane

MOUSE CELLS

Main location

Nuclear membrane

Mouse gene

ENSMUSG00000035020 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA014369	NIH 3T3	Nuclear membrane

GENE INFORMATION
Gene name	EPGN (HGNC Symbol)
Synonyms	ALGV3072, EPG, epigen, PRO9904
Description	Epithelial mitogen (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	74308473 - 74315307
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182585 (version 83.38)
Entrez gene	255324
UniProt	Q6UW88 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UW88
Antibodypedia	EPGN antibodies

PROTEIN BROWSER

EPGN-001	EPGN-003	EPGN-004	EPGN-005	EPGN-006	EPGN-007	EPGN-008	EPGN-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPGN-001 ENSP00000411898 ENST00000413830	Q6UW88 [Direct mapping] Epigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0050679 [positive regulation of epithelial cell proliferation] Show all	154 aa 17.1 kDa	Yes	1
EPGN-003 ENSP00000330375 ENST00000332112	Q6UW88 [Direct mapping] Epigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0050679 [positive regulation of epithelial cell proliferation] Show all	133 aa 14.8 kDa	Yes	1
EPGN-004 ENSP00000426550 ENST00000514968	Q6UW88 [Direct mapping] Epigen Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0050679 [positive regulation of epithelial cell proliferation] Show all	103 aa 11.3 kDa	Yes	0
EPGN-005 ENSP00000425890 ENST00000503098	Q6UW88 [Direct mapping] Epigen Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0050679 [positive regulation of epithelial cell proliferation] Show all	112 aa 12.3 kDa	Yes	0
EPGN-006 ENSP00000426678 ENST00000502358	Q6UW88 [Direct mapping] Epigen Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0005154 [epidermal growth factor receptor binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0050679 [positive regulation of epithelial cell proliferation] Show all	103 aa 11.3 kDa	Yes	0
EPGN-007 ENSP00000426630 ENST00000509145	Q6UW88 [Direct mapping] Epigen Show all	Predicted intracellular proteins Show all	GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0005154 [epidermal growth factor receptor binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0050679 [positive regulation of epithelial cell proliferation] Show all	73 aa 8.1 kDa	No	0
EPGN-008 ENSP00000424392 ENST00000505212	Q6UW88 [Direct mapping] Epigen Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0005154 [epidermal growth factor receptor binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0043406 [positive regulation of MAP kinase activity] GO:0045741 [positive regulation of epidermal growth factor-activated receptor activity] GO:0045840 [positive regulation of mitotic nuclear division] GO:0050679 [positive regulation of epithelial cell proliferation] Show all	94 aa 10.3 kDa	Yes	0
EPGN-009 ENSP00000398415 ENST00000446430	H3BM13 [Direct mapping] Epigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000187 [activation of MAPK activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	130 aa 14.3 kDa	No	1