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KCNB2

GENERAL INFORMATION

Gene name

 KCNB2

Gene description

 Potassium channel, voltage gated Shab related subfamily B, member 2

Protein class

 FDA approved drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (HaCaT, HDLM-2, HEK93, SCLC-21H)
HPA (normal tissue):Tissue enhanced (cerebral cortex, spleen)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 KCNB2 (HGNC Symbol)

Synonyms

 Kv2.2

Description

 Potassium channel, voltage gated Shab related subfamily B, member 2 (HGNC Symbol)

Entrez gene summary

 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q21.11

Chromosome location (bp)

 72537391 - 72938349

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182674 (version 83.38)

Entrez gene

 9312

UniProt

 Q92953 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q92953

Antibodypedia

 KCNB2 antibodies

PROTEIN BROWSER
KCNB2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNB2-001
ENSP00000430846
ENST00000523207
Q92953 [Direct mapping]
Potassium voltage-gated channel subfamily B member 2
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Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030425 [dendrite]
GO:0032809 [neuronal cell body membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043204 [perikaryon]
GO:0046982 [protein heterodimerization activity]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:0072661 [protein targeting to plasma membrane]
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 911 aa
102.6 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.