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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TSKU
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TSKU

Gene description

Tsukushi, small leucine rich proteoglycan

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA008164
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), prostate cancer (favourable), pancreatic cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Prostate cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA008164

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic staining was observed in most cancer types. Strong cytoplasmic staining was observed in several cases of melanoma, liver and colorectal cancer.

GENE INFORMATION

Gene name

TSKU (HGNC Symbol)

Synonyms

E2IG4, LRRC54, TSK

Description

Tsukushi, small leucine rich proteoglycan (HGNC Symbol)

Entrez gene summary

Chromosome

11

Cytoband

q13.5

Chromosome location (bp)

76782251 - 76798154

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182704 (version 83.38)

Entrez gene

25987

UniProt

Q8WUA8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8WUA8

Antibodypedia

TSKU antibodies

PROTEIN BROWSER

TSKU-001
TSKU-002
TSKU-003
TSKU-004
TSKU-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TSKU-001
ENSP00000332668
ENST00000333090
Q8WUA8 [Direct mapping]
Tsukushin
A0A024R5J8 [Target identity:100%; Query identity:100%]
Leucine rich repeat containing 54, isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
353 aa
37.8 kDa
Yes 0
TSKU-002
ENSP00000435133
ENST00000533752
E9PLG7 [Direct mapping]
Tsukushin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
150 aa
16.1 kDa
Yes 0
TSKU-003
ENSP00000434873
ENST00000525167
E9PN12 [Direct mapping]
Tsukushin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
105 aa
11.2 kDa
Yes 0
TSKU-004
ENSP00000434847
ENST00000527881
Q8WUA8 [Direct mapping]
Tsukushin
A0A024R5J8 [Target identity:100%; Query identity:100%]
Leucine rich repeat containing 54, isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0010468 [regulation of gene expression]
GO:0021540 [corpus callosum morphogenesis]
GO:0021670 [lateral ventricle development]
GO:0021960 [anterior commissure morphogenesis]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0043010 [camera-type eye development]
GO:0061073 [ciliary body morphogenesis]
Show all
353 aa
37.8 kDa
Yes 0
TSKU-201
ENSP00000482145
ENST00000612930
Q8WUA8 [Direct mapping]
Tsukushin
A0A024R5J8 [Target identity:100%; Query identity:100%]
Leucine rich repeat containing 54, isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
353 aa
37.8 kDa
Yes 0

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