Expression of TSKU in cancer - Summary - The Human Protein Atlas

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TSKU

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TSKU
Gene description	Tsukushi, small leucine rich proteoglycan
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A549)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA008164
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), prostate cancer (favourable), pancreatic cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Prostate cancer p<0.001 Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008164

GENE INFORMATION
Gene name	TSKU (HGNC Symbol)
Synonyms	E2IG4, LRRC54, TSK
Description	Tsukushi, small leucine rich proteoglycan (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.5
Chromosome location (bp)	76782251 - 76798154
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182704 (version 83.38)
Entrez gene	25987
UniProt	Q8WUA8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WUA8
Antibodypedia	TSKU antibodies

PROTEIN BROWSER

TSKU-001	TSKU-002	TSKU-003	TSKU-004	TSKU-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSKU-001 ENSP00000332668 ENST00000333090	Q8WUA8 [Direct mapping] Tsukushin A0A024R5J8 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 54, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	353 aa 37.8 kDa	Yes	0
TSKU-002 ENSP00000435133 ENST00000533752	E9PLG7 [Direct mapping] Tsukushin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	150 aa 16.1 kDa	Yes	0
TSKU-003 ENSP00000434873 ENST00000525167	E9PN12 [Direct mapping] Tsukushin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	105 aa 11.2 kDa	Yes	0
TSKU-004 ENSP00000434847 ENST00000527881	Q8WUA8 [Direct mapping] Tsukushin A0A024R5J8 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 54, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0010468 [regulation of gene expression] GO:0021540 [corpus callosum morphogenesis] GO:0021670 [lateral ventricle development] GO:0021960 [anterior commissure morphogenesis] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0043010 [camera-type eye development] GO:0061073 [ciliary body morphogenesis] Show all	353 aa 37.8 kDa	Yes	0
TSKU-201 ENSP00000482145 ENST00000612930	Q8WUA8 [Direct mapping] Tsukushin A0A024R5J8 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 54, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	353 aa 37.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.