Expression of PAPPA in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PAPPA

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PAPPA
Gene description	Pregnancy-associated plasma protein A, pappalysin 1
Protein class	Cancer-related genes Candidate cardiovascular disease genes Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, ASC TERT1, TIME, U-138 MG, U-87 MG)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblastic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA001667 , CAB016724
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001667	CAB016724

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Several endometrial- and testicular cancers displayed moderate to strong cytoplasmic immunoreactivity. Remaining cancer tissues were in general weakly stained or negative.

GENE INFORMATION
Gene name	PAPPA (HGNC Symbol)
Synonyms	ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Description	Pregnancy-associated plasma protein A, pappalysin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q33.1
Chromosome location (bp)	116153804 - 116402322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000182752 (version 83.38)
Entrez gene	5069
UniProt	Q13219 (UniProt - Evidence at protein level)
neXtProt	NX_Q13219
Antibodypedia	PAPPA antibodies

PROTEIN BROWSER

PAPPA-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAPPA-001 ENSP00000330658 ENST00000328252	Q13219 [Direct mapping] Pappalysin-1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004222 [metalloendopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0007565 [female pregnancy] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0044267 [cellular protein metabolic process] Show all	1627 aa 181 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.