Fields »
ABOUT
HELP
BLOG
MAFA

GENERAL INFORMATION

Gene name

 MAFA

Gene description

 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (MCF7, SCLC-21H, T-47d, U-2 OS)
HPA (normal tissue):Group enriched (skeletal muscle, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MAFA (HGNC Symbol)

Synonyms

 hMafA, RIPE3b1

Description

 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A (HGNC Symbol)

Entrez gene summary

 MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 143419182 - 143430406

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182759 (version 83.38)

Entrez gene

 389692

UniProt

 Q8NHW3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NHW3

Antibodypedia

 MAFA antibodies

PROTEIN BROWSER
MAFA-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAFA-001
ENSP00000328364
ENST00000333480
Q8NHW3 [Direct mapping]
Transcription factor MafA
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007263 [nitric oxide mediated signal transduction]
GO:0009749 [response to glucose]
GO:0030073 [insulin secretion]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
Show all
 353 aa
37 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.